Eric R . Kandel Genes , synapses and memory storage
نویسنده
چکیده
Genes, synapses and memory storage Professor Eric R. Kandel received the Dr A.H. Heineken Prize for Medicine 2000 for his pioneering research on the molecular mechanisms underlying learning processes and memory.
منابع مشابه
The molecular biology of memory storage: a dialog between genes and synapses.
The biology of learning, and short-term and long-term memory, as revealed by Aplysia and other organisms, is reviewed.
متن کاملStructural Components of Synaptic Plasticity and Memory Consolidation.
Consolidation of implicit memory in the invertebrate Aplysia and explicit memory in the mammalian hippocampus are associated with remodeling and growth of preexisting synapses and the formation of new synapses. Here, we compare and contrast structural components of the synaptic plasticity that underlies these two distinct forms of memory. In both cases, the structural changes involve time-depen...
متن کاملSynaptic remodeling, synaptic growth and the storage of long-term memory in Aplysia.
Synaptic remodeling and synaptic growth accompany various forms of long-term memory. Storage of the long-term memory for sensitization of the gill-withdrawal reflex in Aplysia has been extensively studied in this respect and is associated with the growth of new synapses by the sensory neurons onto their postsynaptic target neurons. Recent time-lapse imaging studies of living sensory-to-motor ne...
متن کاملNeuralized1 Activates CPEB3: A Function for Nonproteolytic Ubiquitin in Synaptic Plasticity and Memory Storage
The cytoplasmic polyadenylation element-binding protein 3 (CPEB3), a regulator of local protein synthesis, is the mouse homolog of ApCPEB, a functional prion protein in Aplysia. Here, we provide evidence that CPEB3 is activated by Neuralized1, an E3 ubiquitin ligase. In hippocampal cultures, CPEB3 activated by Neuralized1-mediated ubiquitination leads both to the growth of new dendritic spines ...
متن کاملInterview with eric R. Kandel: from memory, free will, and the problem with Freud to fortunate decisions.
Eric R. Kandel shared the Nobel Prize for Physiology or Medicine with Arvid Carlsson and Paul Greengard in 2000 for their discoveries concerning signal transduction in the nervous system. Eric Kandel was rewarded for his discoveries of molecular mechanisms underlying learning and memory. He is a Howard Hughes Medical Institute Senior Investigator at Columbia Universities Center for Neurobiology...
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تاریخ انتشار 2003